Bioprocess Engineering Mcqs

Q:

Which sort of Fermenter is used for the production of Penicillin?

A) Batch Fermenter, Fed-Batch Process B) Fed-Batch Fermenter, Fed-Batch Process
C) Continuous Batch Fermenter , Fed-Batch Process D) Fed-Batch Fermenter, Batch process
 
Answer & Explanation Answer: A) Batch Fermenter, Fed-Batch Process

Explanation: For Large production of Penicillin a Batch Fermenter, and a Fed-Batch Process is normally used to prolong the stationary period and so as to increase the production of Penicillin and Batch is used over continuous fermenter for large scale production and fed-batch process is used to overcome its disadvantages.

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60
Q:

What is Slurry which is used in the Penicillin production process?

A) Semi – Liquid mixture B) Solid – Liquid mixture
C) Gas – Liquid mixture D) Liquid
 
Answer & Explanation Answer: A) Semi – Liquid mixture

Explanation: The Semi – Liquid mixture also known as “Undigested Slurry “which goes under the fermentation / anaerobic process and later on comes out as byproduct of fermentation process as “Digested Slurry”.

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Q:

Penicillin production occurs in which growth phase?

A) Lag phase B) Log phase
C) Stationary phase D) Death phase
 
Answer & Explanation Answer: C) Stationary phase

Explanation: Like all antibiotics, Penicillin is a secondary metabolite, so is only produced in the stationary phase as Bacteria produce secondary metabolite such as Antibiotics after the active stage (log phase) of the growth cycle.

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125
Q:

Is Penicillium notatum and Penicillium chrysogenum both are same in terms of yield?

A) True B) False
 
Answer & Explanation Answer: B) False

Explanation: Penicillium chrysogenum and Penicillium notatum both yields Penicillin but P.notatum also yields Notatin, P.notatum which was first discovered by Fleming but did not produced large amounts of penicillin in contrast to P.chrysogenum.

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59
Q:

Which type of fermentation was used by Engineers to produce penicillin on large scale during World War 2?

A) Semi-Solid Fermentation B) Deep-Tank Fermentation
C) Biphasic Fermentation D) Solid-State Fermentation
 
Answer & Explanation Answer: B) Deep-Tank Fermentation

Explanation: The Deep-Tank Batch Fermentation in which there is the application of submerged culture technique which was able to produce Penicillin of Approximately 50mg/ml which grew on large scale during World War 2.

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89
Q:

Which biochemist along with Howard Florey and Ernst Chain, designed a lab-scale process to produce enough Penicillin for animal tests?

A) Sir Edward Penley Abraham B) Dr. Norman George Heatley
C) Sir Alexander Fleming D) Dr. Rudolph Emmerich
 
Answer & Explanation Answer: B) Dr. Norman George Heatley

Explanation: Dr. Norman George Heatley was able to develop the technique for efficiently purifying Penicillin in bulk for animal tests and by this, he invented the technique back-extraction.

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60
Q:

In 1928, Alexander Fleming was working on which type of Bacteria also named “Golden Staph”?

A) Streptococcus pneumonia B) Staphylococcal pneumonia
C) Staphylococcus aureus D) Streptococcus aureus
 
Answer & Explanation Answer: C) Staphylococcus aureus

Explanation: Alexander Fleming was trying to isolate the bacterial strains of Staphylococcus aureus, as to make an antibacterial / antibiotic against it because its infection are severe and is the most antibiotic-resistant strain.

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